Rabu, 29 Desember 2010

ScienceDaily Health Headlines

for Wednesday, December 29, 2010

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Key interaction in hepatitis C virus identified (December 29, 2010) -- Scientists have identified a molecular interaction between a structural hepatitis C virus protein and a protein critical to viral replication. This new finding strongly suggests a novel method of inhibiting the production of the virus and a potential new therapeutic target for hepatitis C drug development. ... > full story

Activity of certain stem cell genes linked with worse outcomes in acute myeloid leukemia patients (December 29, 2010) -- Leukemia patients whose cancers express higher levels of genes associated with cancer stem cells have a significantly poorer prognosis than patients with lower levels of the genes, according to new research. ... > full story

Many cancer cells found to have an 'eat me' signal (December 29, 2010) -- Researchers have discovered that many cancer cells carry the seeds of their own destruction -- a protein on the cell surface that signals circulating immune cells to engulf and digest them. On cancer cells, this "eat me" signal is counteracted by a separate "don't eat me" signal that was described in an earlier study. ... > full story

Virus previously linked to chronic fatigue syndrome was a lab contaminant, not cause of disease, new study shows (December 29, 2010) -- A virus previously thought to be associated with chronic fatigue syndrome is not the cause of the disease, a detailed study has shown. The research shows that cell samples used in previous research were contaminated with the virus identified as XMRV and that XMRV is present in the mouse genome. ... > full story

Quitting menthol cigarettes may be harder for some smokers (December 29, 2010) -- Menthol cigarettes may be harder to quit, particularly for some teens and African-Americans, who have the highest menthol cigarette use, according to a new study. ... > full story

New clues uncover how 'starvation hormone' works (December 28, 2010) -- Researchers may solve a 17-year-old mystery about how the so-called "starvation hormone" affects multiple biological systems, including preventing insulin sensitivity and promoting cell survival. ... > full story

Malaria-infected cells stiffen, block blood flow (December 28, 2010) -- Researchers have completed the first modeling, followed by experiments, of how red blood cells are infected by a malarial parasite that attacks the brain. The researchers report that infected cells stiffen by as much as 50 times more than healthy cells. Infected cells also tend to stick along blood vessel walls, impeding the flow of blood to critical organs. ... > full story

Exposure to North Dakota road material may increase risk of lung cancer (December 28, 2010) -- New data shows that people exposed to the mineral erionite found in the gravel of road materials in North Dakota may be at significantly increased risk of developing mesothelioma, a type of lung cancer most often associated with asbestos exposure. ... > full story

Newborns with low vitamin D levels at increased risk for respiratory infections (December 28, 2010) -- The vitamin D levels of newborn babies appear to predict their risk of respiratory infections during infancy and the occurrence of wheezing during early childhood, but not the risk of developing asthma. ... > full story

High red blood cell folate levels linked to silenced tumor-suppressors (December 28, 2010) -- A study of 781 people enrolled in a colorectal cancer prevention clinical trial finds that elevated levels of red blood cell folate is associated with the deactivation of two anti-cancer genes known to be silenced in colorectal cancer. ... > full story

Psychologists find skill in recognizing faces peaks after age 30 (December 28, 2010) -- Scientists have made the surprising discovery that our ability to recognize and remember faces peaks at age 30 to 34, about a decade later than most of our other mental abilities. ... > full story

Not all infant formulas are alike: Differential effects on weight gain (December 28, 2010) -- New findings reveal that weight gain of formula-fed infants is influenced by the type of formula the infant is consuming. The findings highlight the need to understand the long-term influences of infant formula composition on feeding behavior, growth and metabolic health. ... > full story

Some brain tumors mimic the genetic program of germline cells (December 28, 2010) -- Scientists have discovered that some brain tumors in larvae of the fruit fly Drosophila melanogaster use the genetic program of germline cells to grow. The removal of some of these genes leads to healthy brains. This finding demonstrates that these genes are crucial for tumor development. ... > full story

Features of the metabolic syndrome common in persons with psoriasis (December 28, 2010) -- Individuals with psoriasis have a high prevalence of the metabolic syndrome, according to a new study. ... > full story

Prayer can help people handle difficult emotions, study suggests (December 28, 2010) -- Those who choose to pray find personalized comfort during hard times, according to a sociologist. The 75 percent of Americans who pray on a weekly basis do so to manage a range of negative situations and emotions -- illness, sadness, trauma and anger -- but just how they find relief has gone unconsidered by researchers. ... > full story

Structure of key molecule in immune system provides clues for designing drugs (December 28, 2010) -- A research team has deciphered a key step in an evolutionarily old branch of the immune response. This system, called complement, comprises a network of proteins that "complement" the work of antibodies in destroying foreign invaders. Complement proteins mark both bacterial and dying host cells for elimination by the body's cellular cleanup services and have been implicated in at least 30 diseases. The findings provide a molecular scaffold for designing novel drug therapeutics. ... > full story

New study upends thinking about how liver disease develops (December 28, 2010) -- In the latest of a series of related papers, researchers present a new and more definitive explanation of how fibrotic cells form, multiply and eventually destroy the human liver, resulting in cirrhosis. In doing so, the findings upend the standing of a long-presumed marker for multiple fibrotic diseases and reveal the existence of a previously unknown kind of inflammatory white blood cell. ... > full story

New cell biological mechanism that regulates protein stability in cells uncovered (December 28, 2010) -- The cell signaling pathway known as Wnt, commonly activated in cancers, causes internal membranes within a healthy cell to imprison an enzyme that is vital in degrading proteins, preventing the enzyme from doing its job and affecting the stability of many proteins within the cell, researchers have found. ... > full story

Outcomes after recurrence of oral cancer vary by timing, site (December 28, 2010) -- Patients who have recurrence of oral squamous cell carcinoma tend to do worse if the new cancer appears at the same site early or if it appears in the lymph nodes six months or longer after initial treatment, according to a new study. ... > full story

Bonding with newborn baby: Once upon a time in the Intensive Care Unit ... (December 28, 2010) -- The first few days after birth is an important time when babies learn to recognize the sound of their parents' voice and the parents in turn bond with their children. However, the separation between parents and newborns admitted to the NICU can disrupt the early development of this relationship. Innovative research suggests reading to newborns in the NICU allows parents to feel closer to their babies during this difficult period. ... > full story

Human immune system has emergency backup plan (December 27, 2010) -- New research reveals that the immune system has an effective backup plan to protect the body from infection when the "master regulator" of the body's innate immune system fails. ... > full story

Platinum and blue light combine to combat cancer (December 27, 2010) -- When it comes to health care blue lights, are usually most useful on the top of ambulances but now new research has found a way to use blue light to activate what could be a highly potent platinum-based cancer treatment. ... > full story

A new surgical tool -- the IKEA pencil (December 27, 2010) -- IKEA pencils are better at marking out cuts in the bone for facial and head surgery than traditional felt tipped pens, say two surgeons. ... > full story

Genetic variant that can lead to severe impulsivity identified (December 27, 2010) -- Scientists have found that a genetic variant of a brain receptor molecule may contribute to violently impulsive behavior when people who carry it are under the influence of alcohol. ... > full story

Compound that prevents the growth of prostate cancer cells identified (December 27, 2010) -- Researchers have demonstrated that an antibiotic called "monensin" prevents the growth of prostate cancer cells. Monensin is used in the meat and dairy industry, for example. ... > full story

Supercomputing research opens doors for drug discovery (December 27, 2010) -- A quicker and cheaper technique to scan molecular databases could put scientists on the fast track to developing new drug treatments. ... > full story

Study identifies genetic mutations associated with tumor of adrenal gland (December 27, 2010) -- Analysis has identified variations of a gene that are associated with a type of tumor that forms within the adrenal gland, according a new study. The age group in which these variations were found are frequently excluded from genetic screening models for this type of tumor. ... > full story

Electronic medical records not always linked to better care in hospitals, study finds (December 27, 2010) -- Use of electronic health records by hospitals across the United States has had only a limited effect on improving the quality of medical care, according to a new study. ... > full story

Learning to read the genome: Most detailed annotation of fruit-fly genome points way to understanding all organisms' genomes (December 27, 2010) -- Scientists have recently made major advances in understanding the complex relationships between the Drosophila genome, as recorded by DNA and RNA base pairs, and the patterns and physical organization of its chromosomes. These insights into reading the genome will apply to many organisms, including human beings. ... > full story

Protein targeted to stop melanoma tumor growth (December 27, 2010) -- Halting the growth of melanoma tumors by targeting the MIC-1 protein that promotes blood vessel development in tumors may lead to better treatment of this invasive and deadly cancer, according to new research. ... > full story

Circulating tumor cells predicted recurrence, death in patients with early-stage breast cancer (December 27, 2010) -- The presence of one to four circulating tumor cells (CTCs) in the blood of early-stage breast cancer patients almost doubled patient's risk of cancer relapse and death, and five or more CTCs increased recurrence by 400 percent and death by 300 percent, according to Phase III results of the SUCCESS trial. These cells were found in patients after surgery but before chemotherapy treatment. ... > full story

Treating women’s depression might help them lose weight (December 27, 2010) -- For many women coping with obesity and depression, new research finds that improving your mood might be the link to losing weight. ... > full story

New rule predicts risk of stroke, death from surgery that prevents it (December 27, 2010) -- It's a medical Catch-22: carotid artery surgery can itself cause stroke, but so can asymptomatic carotid disease if left untreated. Researchers have now developed a clinical risk prediction rule using factors such as sex, race and health history to assess the danger the surgery poses, while a modified version will help patients make a more fully informed choice about whether to have the procedure. ... > full story

Fighting cancer and steering immune reactions: New mechanism for reversible proteasome inhibition (December 27, 2010) -- In their function as cellular recycling plants, proteasomes fulfill a life-sustaining role in all cells -- including cancer cells. When the proteasomes become inhibited, cells suffocate in their own waste. A recently discovered reversible proteasome inhibition may provide the key to more specific anti-cancer drugs and to controlling rejection reactions in transplantations. ... > full story

Poor breast cancer prognosis associated with presence of circulating tumor, cancer stem cells (December 27, 2010) -- Metastatic breast cancer patients whose blood contains circulating tumor cells before or after treatment with high-dose chemotherapy and blood stem cell transplant have shorter survival periods, according to a new study. ... > full story

Recovering from job loss: Most report few long-term psychological effects, study finds (December 27, 2010) -- Losing a job is a profoundly distressing experience, but the unemployed may be more resilient than previously believed -- the vast majority eventually end up as satisfied with life as they were before they lost their jobs, according to a new analysis. ... > full story

Part of brain that suppresses instinct identified (December 26, 2010) -- New research is revealing which regions in the brain fire up when we suppress an automatic behavior such as the urge to look at other people in an elevator. Researchers showed -- for the first time -- an increase in signal from the left inferior frontal cortex when study participants were confronted by a conflict between an image and a word superimposed on the image. ... > full story

Mammalian aging process linked to overactive cellular pathway (December 26, 2010) -- Researchers have linked hyperactivity in the mechanistic target of rapamycin complex 1 cellular pathway to reduced ketone production in the liver, which is a well-defined physiological trait of aging in mice. During sleep or other times of low carbohydrate intake, the liver converts fatty acids to ketones, which are vital sources of energy during fasting, especially for the heart and brain. As animals age, their ability to produce ketones in response to fasting declines. ... > full story

Powerful new defibrillator: Minimally invasive surgeries mean smaller scars, quicker recovery (December 26, 2010) -- St. Michael's Hospital has become the first in Ontario to implant a small but powerful new defibrillator into a patient's chest. The defibrillator – about the size of a Zippo lighter – is the smallest available in terms of surface area and can deliver the highest level of energy, 40 joules. ... > full story

Robotic surgery for head and neck cancer shows promise (December 26, 2010) -- Less-invasive robotic surgery for upper airway and digestive track malignant tumors is as effective as other minimally invasive surgical techniques based on patient function and survival, according to researchers. ... > full story

Potential target for breast cancer therapy (December 26, 2010) -- Overexpression or hyperactivation of ErbB cell-surface receptors drives the growth of many breast cancers. Drugs, like Herceptin, that block the receptors' signals halt tumor progression in some patients. However, not all patients' tumors respond, with some becoming resistant over time. Researchers found a protein called P-Rex1 is crucial for signal transmission from ErbB receptors and is overexpressed in nearly 60 percent of breast cancer samples tested. ... > full story

Which comes first: Exercise-induced asthma or obesity? (December 26, 2010) -- Obese people are more likely to report exercise as a trigger for asthma. Of 673 people evaluated in a new study, 71 percent of participants reported exercise-induced asthma. ... > full story

Imagine your future self: Will it help you save money? (December 26, 2010) -- Why do people choose present consumption over their long-term financial interests? A new study finds that consumers have trouble feeling connected to their future selves. ... > full story

Preplay: How past experiences subconsciously influence behavior (December 24, 2010) -- Researchers report for the first time how animals' knowledge obtained through past experiences can subconsciously influence their behavior in new situations. ... > full story

Arsenic agent shuts down two hard-to-treat cancers in animal experiments (December 24, 2010) -- Researchers have found that an arsenic-based agent already FDA-approved for a type of leukemia may be helpful in another hard-to-treat cancer, Ewing's Sarcoma (ES). The research, based on animal studies, also suggests the drug might be beneficial in treating medulloblastoma, a highly malignant pediatric brain cancer. ... > full story

Emerging drug class may enhance red blood cell production in anemic patients (December 24, 2010) -- By determining how corticosteroids act to increase production of red blood cell progenitors, researchers have identified a class of drugs that may be beneficial in treating some erythropoietin-resistant anemias. One such anemia is Diamond-Blackfan anemia (DBA), which is frequently treated with corticosteroids, despite their severe side-effects. The identified class of drugs may be able to treat other anemias, including those resulting from trauma, sepsis, malaria, kidney dialysis and chemotherapy. ... > full story

Site in brain where leptin may trigger puberty identified (December 24, 2010) -- Researchers have pinpointed a tiny site in the brain where the hormone leptin may help trigger the onset of puberty. ... > full story

Fast sepsis test can save lives (December 24, 2010) -- Blood poisoning can be fatal. If you suffer from sepsis, you used to have to wait as much as 48 hours for laboratory findings. A new diagnostic platform as big as a credit card will now supply the analysis after as little as an hour. This system is based on nanoparticles that are automatically guided by magnetic forces. ... > full story


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